Mol. wt. 363.4 Form White crystalline solid. M.p. 220.9–222.2 °C Kow logP = –0.81 (pH 4); –1.52 (pH 7); –2.34 (pH 9) (all 20 °C, 99.9%) S.g./density 1.411 (20 °C) Solubility In water 510 mg/l (pH 3.1), >100 g/l (pH >9.0) (both 20 °C). In isopropanol, acetone, acetonitrile, n-heptane, ethyl acetate, toluene <1.0, methylene chloride 2.5–2.9, DMF 11.4–13.3 (all in g/100 ml, 20 °C) (EC DAR). Stability Stable in aqueous solution for 5 d (pH 4, 7 and 9, 50 °C) and for 30 d (pH 5, 7 and 9, 25 °C). Photolytically stable for 17 d in sterile aqueous solution (pH 5 and 9, 22 °C). pKa 4.06 (20 °C)
TOXICOLOGY
Oral Acute oral LD50 for rats >2000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. Slight eye and skin irritant. Not a skin sensitiser. Inhalation LC50 for rats >5 mg/l. NOEL NOAEL for male rats 0.4 mg/kg b.w. daily.
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